The research results showed a decrease in the total score averages of Bcl-2 immunoexpression which was gradual from normal placenta that showed strong immunoexpression with maximal score (6), then partial hydatidiform mole (3.09), complete hydatidiform mole (2.36), invasive mole (1.18), until choriocarcinoma with negative immunoexpression (score 0) (Figure 6). The gene discussed is BCL2; the disease is invasive hydatidiform mole.