In our previous study of PS on survival in HCC patients (n = 1003), a worse PS was significantly associated with age, gender, Child-Pugh classification, HCC stage, JIS score, initial treatment option for HCC, maximum tumor size, alanine aminotransferase value, hypoalbuminemia, hyperbilirubinemia, renal insufficiency, hyponatremia, and prothrombin and poorer PS was an independent predictor linked to OS with a hazard ratio of 1.773 (P < 0.001). This evidence concerns the gene F2 and hepatocellular carcinoma.