As exhausted CD8+ T cells are known to co-express TIM-3 and PD-1 (refs 7, 8, 9, 10, 11, 12) and co-induce T-bet and Eomes with terminal differentiation28, we studied T-bet and Eomes levels in our tumor-infiltrating CD8+ T cells. The gene discussed is HAVCR2; the disease is neoplasm.