MBTPS1 and cancer: We chose safingol (L-theo dihydrospingosine) rather than a more specific SPHK1 inhibitor or SPHK1 knock down by siRNA mediated knock down of SPHK1, since it is the most developed SPHK1/S1P inhibitor as an anti-cancer agent and in particular safingol has demonstrated safety in combination with cisplatin in a phase I clinical trial and lead to decreased serum S1P in treated patients [38].