Our finding of an inverse relationship between SPHK1 and SGPL1 expression in gastroesophageal cancer associated with increased levels of S1P and cytotoxic drug resistance is consistent with a recent report in prostate cancer, where a similar inverse relationship between expression of SPHK1 and SGPL1 was noted leading to increased production of S1P and an association with resistance to docetaxel [37]. Here, SPHK1 is linked to Familial prostate cancer.