SPHK1 and neoplasm: SPHK1 IHC Quick-score = intensity x proportion: intensity scored as 0 = negative, 1 = weak, 2 = moderate and 3 = strong SPHK1 staining in tumour cells; positive proportion scored as 0 = 0 %, 1 = 1-10 %, 2 = 11-50 %, 3 = 51-70 %, and 4 = > 70 % tumour cells positive for SPHK1 staining.