Only Tumour stage remained significant in a multivariate analysis with the input variables SPHK1 (negative or weak versus moderate or strong), surgical resection margins(positive versus negative), histology (squamous versus adenocarcinoma), site (oesophagus versus gastric) neo-adjuvant chemotherapy (yes versus no) and tumour stage (I or II versus III). This evidence concerns the gene SPHK1 and adenocarcinoma.