TUBA1A-related cortical dysgenesis typically shows a posteriorly predominant lissencephaly with cerebellar hypoplasia (LCH), dysmorphic basal ganglia, thin or absent corpus callosum, congenital microcephaly, ventricular dilatation, and abnormalities of the hippocampus and brainstem16. Here, TUBA1A is linked to microcephaly.