SIRT1 and cancer: According to the allOnco database (http://www.bushmanlab.org/links/genelists), most of their targets are cancer-associated genes such as SIRT1, VEGFA, RASA1, RAF1, PTEN, MAPK9, MAPK8, MAPK1, MYC, MYB, KRAS, JAK2, IGF1R, IDH2, FOXO3, FOXO1, E2F3, E2F1, MAPK14, CDKN2A, CDKN1A, CDK6, CD44, CCNF, CCNE1, CCND3, CCND2, RUNX2, BCL2, CCND1, APC, AKT2, AKT1, ABCA1, etc.