According to the allOnco database (http://www.bushmanlab.org/links/genelists), most of their targets are cancer-associated genes such as SIRT1, VEGFA, RASA1, RAF1, PTEN, MAPK9, MAPK8, MAPK1, MYC, MYB, KRAS, JAK2, IGF1R, IDH2, FOXO3, FOXO1, E2F3, E2F1, MAPK14, CDKN2A, CDKN1A, CDK6, CD44, CCNF, CCNE1, CCND3, CCND2, RUNX2, BCL2, CCND1, APC, AKT2, AKT1, ABCA1, etc. The gene discussed is APC; the disease is cancer.