A small molecule azithromycin inhibits TLR4-related NF-κB activity, which leads to reduction of M1 and increase of M2 cytokines;17 TAMs challenged with zoledronic acid achieved M1 phenotypes with increase of NF-κB-inducible M1 cytokines expression;18 miRNAs-containing exosomes derived from Epigallocatechin gallate-treated tumour cells could be absorbed by TAMs, and led to elicited NF-κB-associated M1 skewing.19 But the role of NF-κB in TAM polarisation is far more complicated and not just depends on the expression level of NF-κB components. Here, NFKB1 is linked to neoplasm.