IKKα is a tumour promoter in the context of colorectal cancer that is responsible in blocking the recruitment of M1-like myeloid cells.58 IKKα and RelB are important regulators of non-canonical NF-кB signalling and p100 processing contributes to the activation of RelB/p52 complex, while TRAF2 negatively regulates the pathway.59 Inactive form of RelB is associated with IкBα and it mobilises to nucleus followed by IкBα degradation.60 RelB is associated with p52 to activate transcription of target genes. The gene discussed is TRAF2; the disease is colorectal cancer.