KIDINS220 and Cerebral ischemia: We used a mice model of focal cerebral ischemia produced by distal occlusion of middle cerebral artery (dMCAO) where NMDAR overactivation is the major mechanism of neurodegeneration.27 MCA compression for 1 h followed by 24 h reperfusion induced large infarcts in cortical areas of this artery territory (Figure 2a).37 We compared Kidins220 levels in the infarcted and corresponding contralateral regions (average infarct volume 29.9±4 mm3; n=4 animals) observing an important decrease in FL-Kidins220 (Figure 2b).