BOK and lung carcinoma: Earlier studies with H1299 lung cancer cell lines similarly suggested that BOK functions as a trigger that sensitizes cells to undergo apoptosis upon drug treatment, rather than act as an effector of cell death.35 Intriguingly, certain cell types from Bok−/− mice were shown to die at a faster rate compared with WT controls when treated with Brefeldin A, a drug that induces Golgi/ER stress.