Earlier studies have demonstrated that mice reconstituted with DKO FLCs developed inflammation and necrotizing vasculitis in several organs.23 To assess whether the additional loss of BOK (on top of loss of BAX and BAK) in hematopoietic cells would lead to more severe disease, various tissues from sick TKO chimeras were examined blinded, and scored on a scale of 0–3 for lymphocytic infiltration (tissues from WT control and Bax−/−Bak−/−DKO FLC reconstituted mice were included for comparison). Here, BAX is linked to necrotizing vasculitis.