RCAN1 and neoplasm: Single extra transgenic copy of Dscr1 is sufficient to confer significant suppression of tumor growth in mice, and that such resistance has thought to be a consequence of a deficit in tumor angiogenesis arising from suppression of the calcineurin pathway.14, 27 Hence, it is reasonable to speculate that cyclosporin A and FK506 (tacrolimus), immunosuppressive drugs that specifically inhibit calcineurin,28 would also suppress tumor angiogenesis.