Whereas Bcl-2 was paradoxically downregulated in R1 and R2 cells, this was compensated by the marked increase in Mcl-1, corroborating an earlier report indicating Mcl-1 dependency of cisplatin-resistant cancer cells.29 Moreover, R1 cells undergo a switch from oxidative phosphorylation to a Warburg phenotype. The gene discussed is MCL1; the disease is cancer.