BCL2 and cancer: Efforts into understaning the underlying mechanism(s) of cisplatin resistance in cancer cells have unraveled several mechanisms including but not limited to: (1) enhanced DNA repair machinery that allows cancer cell to evade genotoxic stress,11 (2) increase in extrusion of platinum drugs via the expression of plasma membrane transporters12, 13, 14 and (3) loss of p53 function and alterations in Bcl-2 family protein profiles that allow cancer cells to evade apoptosis.15, 16