CASP3 and adenocarcinoma: Pretreatment of HCT116 wt human adenocarcinoma cell line with rosiglitazone effectively stimulated LA-12-induced apoptosis, as demonstrated by significant increase in percentage of the cells with specific phosphatidyl serine externalization (Fig 1A; S1 Fig), and cleavage of caspase-3 and its substrate PARP (Fig 1B).