As an effective stimulation of colon cancer cell apoptosis triggered by the combination of rosiglitazone and LA-12 was associated with activation of mitochondrial pathway (cytochrome c release, drop of MMP, and caspase-9 activation), an involvement of these organelles was further examined in more detail using the cells lacking Bax protein. The gene discussed is CASP9; the disease is malignant colon neoplasm.