VEGFA and neoplasm: In addition, several studies have demonstrated that tumours stimulate neutrophils to promote angiogenesis (e.g., via release of neutrophil-derived VEGF) and immunosuppression, as well as migration, invasion, and metastasis; that may explain the poor prognosis of patients with pretreatment neutrophilia (Donskov, 2013), which may or may not be overcome by therapy (Taichman et al, 1997; Jensen et al, 2009; Carus et al, 2013; Dumitru et al, 2013).