VEGFA and hypertensive disorder: With regard to hypertension, VEGF inhibition has been shown to decrease nitric oxide production, leading to vasculature constriction and a reduction in sodium ion renal excretion, resulting in hypertension (Hood et al, 1998; Van Heeckeren et al, 2007), with evidence of the involvement of other renovascular mechanisms as well (Dechend and Luft, 2008).