Other studies using permeabilized cells derived from growth hormone and prolactin-secreting pituitary GH3 cells [34], human promyelocytic leukemia cells [35], human neutrophils [36], mast cells [37], and regulatory T cells [38] have demonstrated that vesicle formation from the TGN during exocytosis was dependent on PLD. Here, GPLD1 is linked to leukemia.