In view of the data presented here and the literature review, we suggest that the reduction of the tumor growth after ecto-5’-NT overexpression can be attributed to two possible events: 1) an increase of differentiated cells in the tumor mass generated by D283hCD73 that makes the tumor cells less proliferative and 2) the activation of A1 adenosine receptors expressed by D283hCD73 cells, which can promote apoptosis and slow tumor growth. This evidence concerns the gene ADORA1 and neoplasm.