EGFR and metastatic colorectal cancer: Anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs), such as panitumumab (Vectibix®, a recombinant, fully human IgG2 mAb) and cetuximab (Erbitux®, a recombinant, chimeric mouse/human IgG1 mAb), bind with high affinity and specificity to the EGFR, and have been shown to be effective across all lines of treatment in metastatic colorectal cancer (mCRC) [1–7].