VIM and autoimmune polyendocrinopathy: Translocation of CL on the surface of apoptotic cells and its interaction with protein cofactor(s) such as vimentin produce a new twist in the ever evolving APS field, because it represents a novel potential trigger for “antiphospholipid antibodies.” Vimentin/CL complex as a “new” target antigen in APS unveils possible lines of therapeutic intervention in those patients with clinical signs suggestive of APS, who are persistently negative for the conventional tests but positive for anti-vimentin/CL antibodies [77, 104].