Several inflammatory cytokines such as interleukin- (IL-) 17, IL-10, IL-6, and transforming growth factor- (TGF-) β elevated serum immunoglobulin A (IgA) concentration and small vascular deposition of IgA-related immune complexes are involved in the pathogenesis of HSP [5–7]. This evidence concerns the gene IL6 and hereditary spastic paraplegia.