In this study, we found that the frequencies of circulating CXCR5+CD4+TFH cells and ICOS+CXCR5+CD4+TFH cells in peripheral blood obtained from the children in the acute phage of HSP were significantly higher than those of HCs group, although the frequencies of circulating PD-1+CXCR5+CD4+TFH cells was not significantly different between the children with acute HSP and HCs group. This evidence concerns the gene CD4 and hereditary spastic paraplegia.