Many studies have shown that the production of various immunoglobulins (Ig) such as IgA, IgM, and IgG is closely associated with TFH cells which play important roles in various autoimmune diseases such as ITP, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and IgA nephropathy [22, 26–29]. This evidence concerns the gene CD40LG and systemic lupus erythematosus.