IL-8, a chemokine with a defining ELR (glutamic acid-leucine-arginine) amino acid motif, is known to be associated with proliferation, migration, angiogenesis, and chemosensitivity in colon cancer cells and has been shown to be highly expressed in many human tumors, including colon cancer [44]. This evidence concerns the gene CXCL8 and malignant colon neoplasm.