ACACA and metabolic dysfunction-associated steatohepatitis: Importantly, Piguet and collaborators showed in mice models of nonalcoholic steatohepatitis how hypoxia upregulates genes involved in lipogenesis, like SREBP-1c (sterol-regulatory-element-binding protein-1c), PPAR-gamma (peroxisome-proliferator-activated receptor-gamma), ACC1 (acetyl-CoA carboxylase 1), or ACC2 (acetyl-CoA carboxylase 2), whereas genes involved in lipid metabolism as PPAR-alpha (peroxisome-proliferator-activated receptor-alpha) and CPT-1 (carnitine palmitoyltransferase-1) were downregulated [23].