CHD8 and neuroblastoma: To elucidate the roles of CHD8 in neurodevelopment and address the contribution of its disruption to ASD pathogenesis, three groups have recently reported genome-wide CHD8 binding sites and transcriptomic changes upon shRNA-mediated knockdown of CHD8 expression in neural progenitor cells (NPCs) [25], neural stem cells (NSCs) [26], and SK-N-SH neuroblastoma cells [27].