These biomarkers are acetoacetyl-CoA synthetase (AACS), dipeptidyl-peptidase 4 (DPP4), d-dopachrome tautomerase (DDT), glutamine synthetase (GLUL), and glutathione S-transferase (GST); particularly, the plasma DPP4 and GST levels were highly associated with CCl4-induced liver fibrosis. The gene discussed is HPGDS; the disease is Hepatic fibrosis.