EGFR and Abnormal renal physiology: With a median follow-up of 6.7 years for EGFR, patients that underwent NSS compared to radical nephrectomy had a substantial reduction of incidences of renal dysfunction, yet the beneficial impact of EGFR for the NSS group of patients did not result in improved overall survival over a mean follow-up of 9.3 years for all-cause mortality [27].