Hepatic AR knockout mice with HFD feeding also show hepatic steatosis and insulin resistance, via upregulation of hepatic expression of SREBP-1c, ACC, and PPARγ to increase lipid synthesis and downregulation of PPARα to decrease fatty acid oxidation; interestingly, such effects are evident in males but absent in females [102, 108]. The gene discussed is SREBF1; the disease is fatty liver disease.