AGT and liver dysplastic nodule: In the DN kidney, blood monocytes and tissue macrophages are functionally polarized towards a proinflammatory M1 phenotype [57] and release considerable amounts of proinflammatory, profibrotic, and antiangiogenic factors (TNFα, IL-1, IL-6, plasminogen activator inhibitor-1, matrix metalloproteinases, TGFβ, platelet-derived growth factor, Ang II, and endothelin) [53].