ALS is a multifactorial disease caused by motor neuron degeneration that can be divided into a sporadic (90% of the cases) and a familial form (fALS) whose 20% of mutations (2% of total ALS cases) map throughout the SOD1 gene (coding the Cu, Zn superoxide dismutase) [12, 13]. Here, SOD1 is linked to amyotrophic lateral sclerosis.