GRB2 and essential thrombocythemia: Regarding IL-6 signaling pathway related genes several of them were already presented in Table 2, such as PTPN11, STAT3, JAK1, JAK2, interleukin 6 signal transducer (IL6ST), and growth factor receptor-bound protein 2 (GRB2). IL6ST has been increased in CD34+ cells of JAK2V617F mutation positive ET and PV patients (Table 2). MAP2K1 was significantly increased in CD34+ cells of PV (Table 3). RAF1 and FOS gene expression were increased in ET and PV but do not reach statistical significance compared to controls (Table 3).