In our study, CAPNS1 and HSPA8 were downregulated in PMF and PV, whereas CASP1, IL6ST, and GPX1 were upregulated in PV and ET, respectively; FGFR4 was upregulated in PV patients, augmented by JAK2V617F allele burden. Here, CAPNS1 is linked to acquired polycythemia vera.