Regarding IL-6 signaling pathway related genes several of them were already presented in Table 2, such as PTPN11, STAT3, JAK1, JAK2, interleukin 6 signal transducer (IL6ST), and growth factor receptor-bound protein 2 (GRB2). IL6ST has been increased in CD34+ cells of JAK2V617F mutation positive ET and PV patients (Table 2). MAP2K1 was significantly increased in CD34+ cells of PV (Table 3). RAF1 and FOS gene expression were increased in ET and PV but do not reach statistical significance compared to controls (Table 3). The gene discussed is MAP2K1; the disease is essential thrombocythemia.