In our study, CAPNS1 and HSPA8 were downregulated in PMF and PV, whereas CASP1, IL6ST, and GPX1 were upregulated in PV and ET, respectively; FGFR4 was upregulated in PV patients, augmented by JAK2V617F allele burden. The gene discussed is CASP1; the disease is acquired polycythemia vera.