Recently several IRE1α inhibitors, namely, STF-083010, 3-ethoxy-5,6-dibromosalicylaldehyde, 2-hydroxy-1-naphthaldehyde, toyocamycin, and irestatin, have been found to induce apoptosis in pancreatic cancer cells [121] and in malignant myeloma cells [122]. The gene discussed is ERN1; the disease is familial pancreatic carcinoma.