This was the last study providing the evidence of miRNA-dependent regulation of pyroptosis and is an excellent empirical example of scenario 2 where miRNAs (i.e., miR-30d) increased in CVDs (i.e., diabetic cardiomyopathy) and such increase caused downregulation of negative regulator of pyroptosis (i.e., ARC transcribed by FOXO3a). The gene discussed is ARC; the disease is diabetic cardiomyopathy.