ACE and obesity due to melanocortin 4 receptor deficiency: When we assessed the ACE I/D variant amongst the obese and nonobese population separately, the frequency of DD genotype was found to be significantly higher in the normotensive group (30 versus 44%, p = 0.02) than in the hypertensive obese individuals but its frequency was higher in the hypertensive nonobese individuals (p = 0.03) (Table 4) indicating that the association of ACE I/D polymorphism with hypertension is dependent on obesity status.