ACE and obesity due to melanocortin 4 receptor deficiency: The frequencies of ACE II genotype were significantly higher in controls than the T2DM cases (10.8% versus 1.4%, p = 0.001). ACE DD and ID genotype frequencies were 44.8 and 53.8%, respectively, in T2DM group and 37.7 and 51.5%, respectively, in controls regardless of obesity status (Table 3).