NOTCH1 and small cell lung carcinoma: In a sharp contrast to the above-mentioned findings from NSCLC cells, a recent report has shown that knockdown of NOTCH1 in SCLC cell lines (H69AR and SBC3) promoted EMT and invasion, and forced expression of NICD1 in the H69 SCLC cells had an opposite effect [30], suggesting that inhibition of NOTCH1 may further promote the invasion and metastasis of SCLC.