NOTCH1 and large cell carcinoma: Partly consistent with these findings, Nguyen et al. showed that 50% of the NSCLC tissues (n = 58, consisting of 35 squamous cell carcinomas, 19 adenocarcinomas, and 4 undifferentiated/large cell carcinomas) were positive for NOTCH1 staining, and NOTCH1 was predominantly localized to the membrane and cytosol of the tumor cells [42].