Interestingly, this work also showed that the solid predominant adenocarcinoma (SPA) tissues had a much lower ratio of NOTCH1 positive staining (3 out of 25 were positive) compared to the other two pathological subtypes of adenocarcinomas (26 out of 64 were positive), including the acinar predominant adenocarcinomas (APA) and papillary predominant adenocarcinomas (PPA), suggesting that NOTCH1 may be a useful biomarker for differentiating histological subtypes of lung adenocarcinoma [41]. Here, NOTCH1 is linked to primary progressive aphasia.