On the contrary, inactivation of NOTCH1 signaling by conditional knockout of RBPJ (recombining binding protein suppressor of hairless, also known as CBF1), one of the key transcription cofactors for NICD1, completely abrogated the KrasG12V-induced lung adenocarcinoma formation in LSL-KrasG12V; Rbpj lox/lox mice [25]. Here, RBPJ is linked to lung adenocarcinoma.