In addition, adenoviral expression of NOTCH1 in DMS53 and NCI-H209 SCLC cells was shown to promote growth inhibition by inducing cell cycle arrest at G1 phase, to increase the expression of cell cycle inhibitors p21WAF1/CIP1 and p27KIP1, and to reduce the expression of human achaete-scute homologue-1 (hASH1), a basic-helix-loop-helix (bHLH) transcription factor and a putative oncogene that can cooperate with SV40 T antigen to drive lung carcinogenesis [12, 13]. The gene discussed is NOTCH1; the disease is small cell lung carcinoma.