NOTCH1 and adenocarcinoma: In line with these results, another study showed that the positive NOTCH1 IHC staining was found in 81.5% of the NSCLC tissues (n = 65, consisting of 38 squamous cell carcinomas and 27 adenocarcinomas), and the expression level of NOTCH1 positively correlated with both disease stages and lymph node metastasis [37].