NOTCH1 and non-small cell lung carcinoma: In support of an oncogenic role for NOTCH1, it was reported that the knockdown of NOTCH1 by expressing its short hairpin RNAs (shRNAs) in NOTCH1-positive NSCLC cell lines, including H292, H358, H1650, H1975, and H2170 cells, significantly inhibited their anchorage independent growth in soft agar [14].