Moreover, inactivation of NOTCH1 signaling by expressing a dominant negative form of Mastermind-like-1 (DNMaml1) (without the necessary coding sequences for the recruitment of transcription coactivators [26]), another important transcription cofactor for NICD1, also significantly inhibited the mutant KRAS-dependent lung adenocarcinoma formation in the CC10-CreER; K-RasG12D; Rosa26-DNMaml1-GFP mice [27]. This evidence concerns the gene NOTCH1 and lung adenocarcinoma.