For instance, in the LSL-KrasG12D; Notch1lox/lox mice, conditional knockout of NOTCH1 in the lung by intranasal instillation of adenovirus particles of the Cre recombinase, which also concomitantly induced the expression of KrasG12D in the lung, significantly suppressed the formation of lung adenocarcinomas [23, 24]. This evidence concerns the gene NOTCH1 and lung adenocarcinoma.