EGFR and neoplasm: Interestingly, the expression of NICD1 in H292 cells specifically increased their proliferation and soft agar colony growth in the presence of EGF (epidermal growth factor), but not in the absence of EGF, suggesting that the activation of EGFR (epidermal growth factor receptor) may be essential for NICD1-dependent malignant transformation and tumor growth [14].