NOTCH1 and adenocarcinoma: Recent sequencing of the entire C-terminal region of NOTCH1's coding sequence (CDS), including exons 26, 27, and 34, for 49 NSCLC tissues (consisting of 15 squamous cell carcinomas and 34 adenocarcinomas) identified four heterozygous mutations of NOTCH1 from a total of six tissues (3 squamous cell carcinomas and 3 adenocarcinomas) [40].