Knockdown of Jagged2 by expressing shRNAs inhibited the activation of NOTCH1, suppressed epithelial-mesenchymal transition (EMT) and invasion, and abrogated metastasis in a syngeneic tumor metastasis model using lung adenocarcinoma cell lines derived from the KRASG12D; p53R172HΔG mice [31]. The gene discussed is JAG2; the disease is lung adenocarcinoma.