High FGF23 was associated with each outcome, but the associations were even stronger in CKD (n = 1,128): in this subgroup, compared with the lowest quartile, the highest FGF23 quartile had adjusted hazard ratios (HRs) of 1.9 for all-cause death, 1.9 for incident HF, and 1.5 for incident CVD events, while HRs without CKD were 1.3 for mortality, 1.4 for HF, and 1.1 for CVD [26]. This evidence concerns the gene FGF23 and chronic kidney disease.