The large meta-analysis involving a total sample size of 69,235 subjects [50] confirmed the association of the three NOS3 gene polymorphisms (Glu298Asp, −786 T/C, and 4 a/b) with the presence of CAD, but no significance was found for 4 a/b polymorphism in European population. The gene discussed is NOS3; the disease is coronary artery disorder.