The final clinical score of age, sex, high-sensitivity cTnI concentrations(log10 transformed), Vmax (logetransformed), and ECG strain demonstrated excellent discrimination (cstatistics = 0.85; 95% confidence interval 0.78–0.91; P < 0.001) andcalibration (Hosmer–Lemeshow χ2 = 7.33; P =0.50; Table 2), and itoutperformed other determinants of midwall myocardial fibrosis (Table 3). The gene discussed is TNNI3; the disease is Myocardial fibrosis.