In particular, one cannot simply rely on the traditional markers of AS severity(such as Vmax) as the magnitude of the hypertrophic response andthe rate of LV decompensation are highly variable between patients.1,21–23 Although plasma BNP concentrations were associated with midwallmyocardial fibrosis, the association was absent when other variables were considered. Here, NPPB is linked to aortic stenosis.