The elevation of Osr1, Nanog, HGF, BMP-7, WT-1, and Pax2 expression in CKD rat kidney by Icariin was well in correlation with the increased numbers of CD133+ and/or CD24+ stem/progenitor cells while the reduced expression of TGF-β1 leading to the blocking of interstitial fibrosis (Fig. 7). This evidence concerns the gene NANOG and chronic kidney disease.