We then wondered whether symptomatic AR113Q male mice were characterized by modification of selected markers that we found altered in tg ALS mouse models, such as TGFβ1 (which correlates with muscle fiber damage or atrophy)34, 81, or PGC-1α67 (which regulates energy metabolism and mitochondria biogenesis and functions). The gene discussed is TGFB1; the disease is amyotrophic lateral sclerosis.