Therefore, despite the fact that at 24 wks of age AR113Q male mice already show symptoms of the disease accompanied by signs of muscle atrophy and MyoG activation, the catabolic activity of muscle proteins mediated by atrogin-1, MuRF-1 and Cullin-3 ubiquitin ligases did not take place yet. This evidence concerns the gene FBXO32 and Atrophy.