RPS6 and neoplasm: However, the hyperphosphorylation of rpS6 was significantly more prevalent in larger tumor size (P < 0.001), lymph node invasion (P < 0.001), distant metastasis (P = 0.015) and advanced stage (P < 0.001) patients, whereas the association with sex, age, tumor histological types or histological differentiation was weak (all P > 0.05).