Compared to WT mice, Mras−/− mice also exhibited significantly increased anxiety-like behavior in an open field test (F1,37 = 19.54, p < 0.0001; p = 0.0225 for males; p = 0.0134 for females; Fig. 1g), including significantly more time spent in the corners of the open field (p = 0.0166; Additional file 1: Figure S1B). Here, MRAS is linked to Anxiety.