ESR1 and breast cancer: Based on the integrated raining dataset (Sur-Data1 and Sur-Data2, as described in Table1) for macro-dissected ER+ breast cancer tissues with data of the relapse free survival (RFS), defined as the time period between the date of the first surgery and the date of first relapse, using the univariate Cox model with a FDR < 10%, we identified 17 gene pairs as prognostic gene pairs from the Consistent-Gene-Pairs.