In contrast, nearly all tumor cells and microvessel endothelial cells (arrows in Fig. 3b) in the infiltrating zone were absent of PDCD10 immuno-signal (green) but showed strong PCNA immunoreactivity (red) (Fig. 3b) and appeared negative for caspase 3 staining (Fig. 3c and e). The gene discussed is PDCD10; the disease is neoplasm.