In spite of its well-established pro-angiogenic function [22, 26] and vessel hyper-permeability [13, 14, 28, 29] induced by PDCD10-deficiency, the present study reported for the first time that the downregulation of PDCD10 is inversely associated with MVD (Fig. 4) and with a higher grade of brain edema in GBM (Fig. 5). The gene discussed is PDCD10; the disease is glioblastoma.