MYC and glioblastoma: Transcription of PDCD10 was driven by the binding of c-Myc to a non-canonical E-Box element in the promoter of PDCD10; and moreover, this binding can be interfered by the methylation at a specific nucleotide in this E-Box thereby suppressing the transcription of PDCD10. Whether this mechanism accounts for the downregulation of PDCD10 detected in GBM needs to be further studied in the future.