ACE and Glucose intolerance: Good control of blood pressure and the high prevalence of ACE inhibitors or ARBs in our study population probably mitigated the rise in 2 h blood glucose in the hydrochlorothiazide group, despite the high proportion of patients with central adiposity.33, 34, 35 But results in the amiloride group—in which there were seemingly contrary trends for HbA1c and 2 h glucose concentrations—show previously noted limitations of using HbA1c as a surrogate of glucose intolerance.36