Wnt-independent luminal-like models (MMTV-PyMT and MMTV-Her2) as well as a basal-like BRCA1 tumour model (BLG-Cre:Brca1fl/fl:p53+/–) showed low or negative RUNX2 staining (Fig. 8A). This evidence concerns the gene TP53 and neoplasm.