SIRT1 and myocardial infarction: Up-regulation of SIRT1 significantly reduced myocardial apoptosis in diabetic rats to the extent as in non-diabetic animals following MI/R (Apoptotic index: 27.4 ± 3.2 % of Ad.SIRT1 vs. 40.8 ± 4.6 % of DIR, Fig. 4a, n = 8, P < 0.01).