In addition, our case shares the same clinical features as other SHANK3 deletion cases described in the literature: severe language impairment with impairment of social interactions, impairment of verbal and nonverbal communication, presence of sensory processing dysfunction involving touching and oro-facial activities, developmental delay and intellectual deficiency, hyperactivity and attention disorder, gastrointestinal symptoms and thin corpus callosum on cerebral MRI [3, 30]. Here, SHANK3 is linked to Global developmental delay.