For instance, one of the higher quality studies published in the Lancet by Schottenfeld et al. (2008) provides a list of conditions they deemed problematic for inclusion into the trial without once discussing how such conditions were measured, “Patients were ineligible if they were dependent on alcohol, benzodiazepines, or sedatives; had concentrations of liver enzymes (alkaline phosphatase or alanine transaminase) greater than three times the upper limit of normal; were dangerous to themselves or others; were psychotic or had major depression; or had life-threatening medical problems,” [19]. Here, GPT is linked to major depressive disorder.