Intriguingly, elongated mitochondria, formed by a failure of Drp1 to localize into mitochondria or by decreased Drp1 expression in the Alzheimer’s disease patients, accumulated in the perinuclear region16, 17, where the indications of NLRP3 inflammasome assembly including ASC speck-like aggregates and association between NLRP3 and ASC have also been observed18, 19, 20. Here, NLRP3 is linked to early-onset autosomal dominant Alzheimer disease.