In contrast, while at 96 h post-infection the bacillary load for Rv and Rv∆glmU- infected THP-1 cells remained the same, the addition of ATc to Rv∆glmU- infected THP-1 cells 24 h after infection decreased the pathogen load by ~2.5 log fold, indicating that the reduction of GlmUMtb levels impacts pathogen survival even in an established ex vivo infection (Fig 6B). This evidence concerns the gene ATM and infection.