The known serum biomarkers for HCC include AFP, des-γ-carboxyprothrombin (DCP), fucosylated AFP (AFP-L3), Golgi protein 73 (GP73), isozyme of alkaline phosphatase (variant ALP), and isozyme of gamma-glutamyl transpeptidase (novel γ-GTP)4,.5 Here, AFP is linked to hepatocellular carcinoma.