LAG3 and neoplasm: Loss of LAG3 and PD-1 signaling in Pd1−/−Lag3−/− double-knockout mice resulted in complete rejection of poorly immunogenic tumor in a T-cell-dependent manner, and rejection in the double-knockout mice occurred much more quickly than that in Pd1−/− or Lag3−/− single-knockout mice, suggesting that these two inhibitory pathways can cooperatively suppress antitumor T effector cells26,.27