HAVCR2 and melanoma: TIM3 has also been reported to be co-expressed with PD-1 on tumor-specific CD8+ T cells, and the dual blockade of PD-1 and TIM3 has significantly enhanced the in vitro proliferation and cytokine production of T cells isolated from human melanoma patients, following stimulation with the cancer–testes antigen, NY-ESO-128-.30