Of 586 genes that differ in expression in muscle between old and young men after endurance training (30), four were associated with grip strength in this study: MGST1 (negative direction), an immune mediator that may protect against oxidative stress (49); MCM7 (positive direction), which regulates DNA replication during proliferation (12); CIRBP (positive direction), which promotes inflammation in response to shock and sepsis (38); and ANP32B (negative direction), a cell-cycle progression and antiapoptosis factor (41). The gene discussed is CIRBP; the disease is Sepsis.