IGF2 and type 2 diabetes mellitus: We observe significant associations between muscle strength and expression of IGF1R and IGF2BP2 (positive and negative directions of association with muscle, respectively), growth factors involved in skeletal muscle growth (33, 46); the former is known to enhance cell survival by mediating IGF1 signaling, and the latter modulates IGF2 translation and has genetic variants associated with Type 2 diabetes (19).